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picture1_Gene Knockout Slideshare 67012 | Targetpredictionusingpropagation


 161x       Filetype PPTX       File size 1.71 MB       Source: simons.berkeley.edu


File: Gene Knockout Slideshare 67012 | Targetpredictionusingpropagation
promising drug targets reverse expression signature gene expression connectivity query score lamb et al the connectivity map using gene expression signatures to connect small molecules genes and disease science 2006 ...

icon picture PPTX Filetype Power Point PPTX | Posted on 28 Aug 2022 | 3 years ago
Partial capture of text on file.
     Promising Drug  Targets Reverse Expression 
                     Signature
  Gene 
  Expression                             Connectivity 
  query                                  Score
 Lamb et. al. “The Connectivity Map: using gene-expression signatures to connect small 
 molecules, genes, and disease,” Science, 2006.
            Looking For Drug Targets Using In-Silico 
                       Knockouts in a PPI Network
                    Disease State                           Disease State + Drug
        Mutation                          signal from mutations      inhibition
      Knockout of Good Drug Target Will Reverse 
               the Disease-Related Effects 
                                         Differentially expressed genes
                        propagation
                                      g1 g2 g3 g4 g5 g6 g7 g8 g9 g10
   Patient’s 
   mutation data
      Knockout of Good Drug Target Will Reverse 
               the Disease-Related Effects 
                                         Differentially expressed genes
                        propagation
                                      g1 g2 g3 g4 g5 g6 g7 g8 g9 g10
   Patient’s 
   mutation data
                                      propagation
                         knockout
                            propagation
                                            g1 g2 g3 g4 g5 g6 g7 g8 g9g10
      Knockout of Good Drug Target Will Reverse 
               the Disease-Related Effects 
                                         Differentially expressed genes
                        propagation
                                      g1 g2 g3 g4 g5 g6 g7 g8 g9 g10
   Patient’s 
   mutation data
                                             g1 g2 g3 g4 g5 g6 g7 g8 g9g10
                        knockouts
                            propagation      g1 g2 g3 g4 g5 g6 g7 g8 g9g10
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...Promising drug targets reverse expression signature gene connectivity query score lamb et al the map using signatures to connect small molecules genes and disease science looking for in silico knockouts a ppi network state mutation signal from mutations inhibition knockout of good target will related effects differentially expressed propagation g patient s data gg...

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