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Important drug nutrient
interactions
Pamela Mason
Outline
n What is a drug nutrient interaction?
n Types and mechanisms of interaction
n Influence of drugs on nutrition
n Interactions between supplements and drugs
n Interactions involving St John’s wort and
grapefruit juice
n Risk and implications of interactions
n Patient care
What is a drug nutrient interaction?
That which results from a physical, chemical, physiological or
pathophysiological relationship between a drug and a nutrient.
The interaction is considered significant from a clinical
perspective if therapeutic response is altered (reduced or
enhanced)
Context
n Potential for interactions appear infinite, but
n What proportion of these have been identified?
n What number of the identified subset are
clinically relevant?
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